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6 Surprising Benefits Of Fisetin

While many people are more than happy to jump on the latest trend, it always feels better when you’re at the front of the queue and do something before it becomes popular in the mainstream. While achieving this is often hard, as it can be impossible to be sure what will blow up next, today we want to present you with a great option to help you do just that, as we feel fisetin is sure to be among the next supplements to explode.

A compound that’s only begun being aggressively researched in the past few years, studies show it can benefit the human body in an incredible range of ways. So, if you want to be the next supplement trend setter, this is the article for you. We’ll detail exactly what fisetin is, how it works, and the benefits it offers, to help you get ahead of the pack and try the next big supplement before anyone else.

Table of Contents

What Is Fisetin & How Does It Work?

Fisetin is a flavonoid, which is a type of antioxidant found in many fruits, vegetables, and other plants that creates their taste and colour, while often being able to provide a variety of health benefits. Supplemental use of fisetin is fairly new and stems from recent clinical trials producing evidence that it possesses senolytic properties.

This means it helps the body clear out damaged or “senescent” cells, which accumulate with age and contribute to aging and chronic diseases. Some of fisetin’s studied effects include protecting the cells from oxidative stress, reducing inflammation, supporting brain health and function, particularly concerning memory, regulating blood sugar, improving insulin sensitivity, and potentially even extending your lifespan by reducing senescent cells.

As a supplement that is still largely in its testing phase, the optimal daily dosage of fisetin is yet to be agreed on. That said, the vast majority of studies feel it is somewhere in the 100 to 500 mg per day range, while studies using daily doses as high as 1,200 mg have not produced any negative effects.

6 Surprising Benefits Of Fisetin

Produces Antioxidant & Anti-Inflammatory Effects

Fisetin is best known as a potent antioxidant and anti-inflammatory. It neutralizes reactive oxygen species (ROS), preventing oxidative stress and damage to DNA, proteins, and cell membranes. This boosts the body’s levels of antioxidant enzymes like glutathione peroxidase and superoxide dismutase (SOD), helping to preserve mitochondrial function under stress and protect the body from damage.

This is furthered by its ability to reduce inflammation by inhibiting NF-κB and other pro-inflammatory signalling pathways and decreasing the production of inflammatory cytokines such as TNF-α, IL-6, and IL-1β. This is particularly useful for reducing chronic low-grade inflammation, which is linked to aging and various metabolic disorders (1).

Improves Cardiovascular Function

The anti-inflammatory effects of fisetin also support heart and blood vessel health by reducing oxidative stress throughout the vascular system, which can prevent the development of serious conditions like atherosclerosis.

It then also improves endothelial function by increasing nitric oxide (NO) production and availability. This helps the blood vessels relax and can lower blood pressure and improve circulation, leading to a far healthier, better-functioning cardiovascular system (2).

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Promotes Brain Health

Much like with the heart, fisetin reduces oxidative stress and inflammation in brain tissue, leading to a significant reduction in damage and a great increase in health and functions. Its ability to cross the blood–brain barrier means it is able to directly protect neurons, while many studies show it also boosts the production of brain-derived neurotrophic factor (BDNF), meaning it’s capable of supporting learning, memory, and neuroplasticity.

This combination of effects means it may also protect against the development of neurodegenerative conditions like dementia, Alzheimer’s disease, and Parkinson’s disease (3).

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Reduces The Effects Of Aging

A somewhat unusual benefit of fisetin is that it acts as a senolytic, which means it clears aging cells from the body. It achieves this as it has the ability to selectively trigger apoptosis (better known as programmed cell death) in senescent cells that have stopped dividing but which are still releasing harmful inflammatory molecules.

While this may just seem like another mechanism by which fisetin can reduce inflammation, it specifically relates to aging. Not only are senescent cells primarily found in older people (senex is the Latin word for old man), but removing senescent cells can directly improve tissue function and slow various aspects of aging, including declining health and the development of several chronic health conditions (4).

For more tips on how to age gracefully, check out the article we published dedicated to the topic here.

Regulates Blood Sugar Levels

Some studies suggest that fisetin can regulate blood sugar metabolism and levels through a couple of different mechanisms. The first, as you may by now have guessed, is by reducing inflammation, particularly in the fat tissue and liver.

Reduced inflammation in the fat tissue makes it easier to metabolise, which is beneficial for your blood sugar levels as large amounts of body fat are known to cause insulin resistance. Meanwhile, keeping the liver inflammation free enables it to effectively produce bile, which is a type of acid that plays a significant role in metabolising glucose in the blood and preventing the development of diabetes.

Beyond its anti-inflammatory benefits, though, fisetin also regulates blood sugar levels by improving insulin sensitivity and glucose uptake in the cells. There is evidence to suggest that this combination of effects may also help to prevent complications of metabolic syndrome and type 2 diabetes (5).

Learn some surprising facts about Nicotinamide Riboside here

Potential Anti-Carcinogenic Properties

There is also some evidence to suggest that fisetin may have anti-carcinogenic properties. In lab studies, fisetin has been shown to inhibit tumour cell growth, induce apoptosis in cancer cells (essentially killing them off), and block metastasis-related pathways, so any existing tumours lose the ability to spread to other parts of the body.

These effects are, admittedly, still being researched and are not yet conclusively proven in humans, but the early signs are very promising (6).