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5 Surprising Benefits Of Quercetin Dihydrate

Quercetin dihydrate is a supplement that’s starting to gain some traction, as more and more outlets begin marketing it as a natural miracle compound that benefits the body in countless ways. The problem? Most people have little to no idea about what it is or does, so don’t bother investing in it.

As we agree it really is an amazing compound, we feel that’s a real shame. That’s why we decided to explain everything there is to know about quercetin in this article, to hopefully give you the confidence you need to try it for yourself.

Table of Contents

What Is Quercetin Dihydrate & How Does It Work?

Quercetin is a plant flavonoid most commonly found in apples, but it is also present in other foods like onions, capers, and some berries and leafy greens. It has been well studied and repeatedly shown to produce antioxidant, anti-inflammatory, and immune-modulating effects. It appears to be useful for supporting metabolic health, as well as the health of the brain, joints, and immune and circulatory systems.

Quercetin dihydrate is almost identical to the base version and offers the same benefits, but the inclusion of two water molecules in the compound makes it more stable and soluble. This means it’s more easily absorbed by the body and more effective.

Studies on quercetin dihydrate suggest that daily dosages from 250mg to 1,000mg will produce benefits, without putting you at risk of side effects. However, it’s generally felt that the optimal daily dosage is around 500mg, and suggested that anyone taking a larger daily dose take it in multiple smaller servings no larger than this.

5 Surprising Benefits Of Quercetin Dihydrate

Produces Antioxidant, Anti-Inflammatory, Antimicrobial, & Anti-Viral Effects

Quercetin is best known for its antioxidant, antimicrobial, anti-inflammatory, and anti-viral properties. The primary benefit of these properties is that they enable it to neutralise the free radicals that damage cells and accelerate aging, while also reducing inflammatory pathways and cytokines (1).

This protects the blood vessels, skin, and organs from oxidative stress, and leads to a significant reduction in even chronic cases of inflammation, making it a good way to combat conditions like arthritis and metabolic syndrome. Some studies also show quercetin inhibits the replication of some viruses, such as influenza and coronaviruses, and suppresses harmful bacteria, while supporting the body’s natural defenses against infections.

Improves Heart Health & Circulation

The antioxidant and anti-inflammatory effects of quercetin are particularly beneficial for the heart and arteries. Not only do they neutralise free radicals in the blood vessels and reduce vascular inflammation and oxidative stress, which damage the heart and arteries, but they also slow plaque buildup and stabilize existing plaques, reducing the risk of atherosclerosis.

Quercetin then aids nitric oxide (NO) production, which relaxes blood vessels, boosts circulation, microcirculation (blood flow in small vessels), and blood vessel flexibility and function (endothelial health), prevents arterial stiffness, and supports healthy blood pressure by lowering both systolic and diastolic blood pressure, especially in people with hypertension. Some evidence suggests it promotes mild antiplatelet activity that reduces the risk of blood clots.

Quercetin supplementation even benefits your cholesterol levels, which improves circulation and heart health and functions, by protecting HDL (good) cholesterol from oxidative damage, preserving its beneficial role, and lowering total cholesterol and triglycerides. It also reduces LDL (bad) cholesterol oxidation, which is more likely to form arterial plaque (2).

Discover 5 Benefits of Berberine HCL here

Supports The Immune System

Quercetin supplementation is very beneficial for immunity. Its suppression of certain inflammatory cytokines and pathways calms overactive immune signalling and supports a balanced immune system, helping fight infections and diseases without causing excessive immune overactivation or inflammation, while improving recovery.

The antioxidant, antimicrobial, and antiviral properties of quercetin then benefit the immune system by inhibiting the entry and replication of viruses like influenza, rhinovirus, and some coronaviruses into the body, enhancing its natural defence against those that get in, reducing the activity of certain harmful bacteria and fungi, and neutralising free radicals and protecting white blood cells from oxidative stress to help maintain the function of immune cells under stresses such as illness, aging, and pollution, and reduce the severity and duration of respiratory infections.

Quercetin also acts as a natural antihistamine that stabilizes mast cells, preventing them from releasing histamine and other inflammatory chemicals. This helps reduce the symptoms of seasonal allergies like sneezing, a runny nose, and watery eyes (3).

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Promotes Metabolic Health

Quercetin has a profound effect on a person’s blood sugar levels, as it improves insulin sensitivity, which helps glucose enter the cells more efficiently, lowering fasting blood sugar and reducing spikes after meals. It also reduces glucose production in the liver, to keep levels down, while modulating the enzymes involved in carbohydrate metabolism to slow glucose absorption.

By reducing inflammation and neutralizing the free radicals that damage the cells in the liver, pancreas, and blood vessels, it directly preserves the function of metabolic organs, including the pancreas, which is responsible for insulin production. This is furthered by the improved cholesterol and triglyceride levels it produces.

Some studies even say quercetin activates AMPK, a metabolic master switch that improves mitochondrial function and energy levels and utilization, leading to improved fat burning and weight management (4).

Protects The Brain

By neutralizing the free radicals and oxidative stress in the brain that cause neuroinflammation and damage neurons, quercetin protects the brain cells from mitochondrial damage, age-related breakdown, cognitive decline, and neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases.

For more tips on how to slow the aging process, check out our dedicated article here.

These benefits are furthered by its ability to prevent beta-amyloid plaque accumulation and tau protein tangles, which accelerate these conditions. This also reduces neuronal cell death and supports overall neuron survival and function by enhancing nitric oxide production in blood vessels, improving oxygen and nutrient delivery to the brain, and supporting vascular health, which is critical for cognitive function.

Some studies also suggest that quercetin enhances synaptic plasticity, improving the ability of neurons to form new connections and your memory, focus, and learning capacity (5).